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In a randomized, double-blind, placebo-controlled, factorial trial study 1 , 843 patients were treated with various combinations of metoprolol succinate doses of 25 to 200 mg and hydrochlorothiazide doses of 6.
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Metoprolol has a very low melting point, the tartrate s is around 120 c 248 f , and the succinate s around 136 c 277 f .
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4 major surgery avoid initiation of high-dose extended-release metoprolol in patients undergoing non-cardiac surgery because it has been associated with bradycardia, hypotension, stroke and death.
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Yes, diabetics can take metoprolol but it s not recommended at all for high doses of beta-1 and you must take beta blockers cautiously as per the prescription of the doctor.
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