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Methotrexate may cause you to become sunburned more easily.
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Additionally, concurrent administration of methotrexate and cyclosporine in patients with rheumatoid arthritis can elevate methotrexate concentrations and decrease the levels of the 7-hydroxy-methotrexate metabolite.
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The following is a list of medications which may interact with methotrexate and must be avoided while taking methotrexate.
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Esomeprazole major use caution when administering high-dose methotrexate to patients receiving proton pump inhibitors ppis ; a temporary withdrawal of the ppi should be considered in some patients receiving high-dose methotrexate.
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